ALIMTA 100 mg powder for concentrate for solution for infusion
Sponsors
Summit Therapeutics Inc., Bristol-Myers Squibb Services Unlimited Company, F. Hoffmann-La Roche AG, AstraZeneca AB, PDC line pharma
Conditions
Non-Small Cell Lung CancerNon-small-cell lung cancerPan tumorPatients With EGFR-mutant Locally Advanced or Metastatic Non-squamous NSCLC Who Have Failed to EGFR-TKI TreatmentUntreated Advanced or Metastatic Non-Small Cell Lung Cancer
Phase 1
A Phase Ib/II, Open-Label, Multicenter Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination with Other Anti-Cancer Therapies in Patients with Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer with a KRAS G12C Mutation
RecruitingCTIS2023-507171-22-00
Start: 2023-06-21Target: 116Updated: 2025-10-27
An open-label, dose-escalation, phase I/II study to assess the safety, the tolerability, the immunogenicity and the preliminary clinical activity of the therapeutic cancer vaccine, PDC*lung01, associated or not with anti-PD-1 treatment in patients with non-small-cell lung cancer (NSCLC)
CompletedCTIS2024-517429-24-00
Start: 2020-01-09End: 2025-09-30Target: 64Updated: 2025-06-17
Phase 2
Phase 3
A Randomized, Double-blind, Multi-center, Phase III Study of AK112 or Placebo Combined With Pemetrexed and Carboplatin in Patients With EGFR-mutant Locally Advanced or Metastatic Non-squamous NSCLC Who Have Failed to EGFR-TKI Treatment (HARMONi)
Active, not recruitingCTIS2023-504434-22-00
Start: 2023-10-03Target: 45Updated: 2025-12-16
A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)
Active, not recruitingCTIS2024-511169-12-00
Start: 2023-03-28Target: 87Updated: 2025-11-17