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DRUG14 trials

Sponsors

F. Hoffmann-La Roche AG, Universitair Medisch Centrum Groningen, Oslo University Hospital HF, Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, Rigshospitalet

Conditions

ALK positive non-small cell lung cancerAdvanced ALK-positive non-small cell lung cancer (NSCLC)Advanced CancerAdvanced MalignanciesAdvanced solid tumorAnaplastic Lymphoma Kinase (ALK)-Positive Non-Small Cell Lung Cancer (NSCLC)Anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC)Cancer

Phase 2

A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile: The Drug Rediscovery Protocol (DRUP trial)
RecruitingCTIS2023-509152-33-00
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis StichtingAdvanced solid tumor, Multiple myeloma, Non-Hodgkin lymphoma +1
Start: 2016-07-25Target: 3000Updated: 2025-12-19
An open-label single arm interventional phase 2 study to investigate outcome of individualized treatment based on pharmacogenomic profiling and ex vivo drug sensitivity testing of patient-derived organoids in patients with metastatic colorectal cancer
RecruitingCTIS2023-510092-62-00
Oslo University Hospital HFColorectal cancer
Start: 2022-09-27Target: 45Updated: 2025-06-26
ProTarget - A Danish Nationwide Clinical Trial on Targeted Anti‐Cancer Treatment based on Genomic Profiling
RecruitingCTIS2023-510527-29-00
RigshospitaletCancer
Start: 2020-09-01Target: 600Updated: 2025-04-25
Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Phase II Platform Trial
Active, not recruitingCTIS2023-507418-28-00
F. Hoffmann-La Roche AGSolid tumors
Start: 2021-03-15Target: 407Updated: 2025-12-09
Improving public cancer care by implementing precision medicine in Norway A multi-cohort phase 2 treatment clinical study investigating efficacy of approved drugs outside indication in patients with advanced cancer. IMPRESS-Norway
RecruitingCTIS2023-507894-16-00
Oslo University Hospital HFCancer
Start: 2021-04-01Target: 6000Updated: 2026-01-22
A phase II trial of an individualized treatment strategy for patients with metastatic non-clear cell renal carcinoma
Active, not recruitingCTIS2024-519070-39-00
Region HovedstadenMetastatic non-clear cell renal cell carcinoma
Start: 2020-03-06Target: 30Updated: 2024-10-31
The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs to determine the Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile
Not yet recruitingCTIS2024-517478-68-01
HUS-YhtymaeAdvanced Cancer
Target: 250Updated: 2024-11-06

Phase 3

A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients Selected According to Biomarker Status, with Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer
RecruitingCTIS2023-503920-14-00
F. Hoffmann-La Roche AGNon-Small Cell Lung Cancer (NSCLC)
Start: 2024-01-02Target: 39Updated: 2025-08-11
A Phase III, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients with Completely Resected Stage Ib (Tumors ≥ 4 Cm) to Stage IIIa Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer
Active, not recruitingCTIS2023-506861-76-00
F. Hoffmann-La Roche AGAnaplastic Lymphoma Kinase (ALK)-Positive Non-Small Cell Lung Cancer (NSCLC), Completely resected, Stage Ib (tumors ≥ 4 cm) to Stage IIIa
Start: 2018-08-09Target: 55Updated: 2025-05-26
An open label, multicenter extension study in patients previously enrolled in a Genentch and/or F. Hoffmann-La Roche Ltd sponsored atezolizumab study (IMBRELLA B)
Active, not recruitingCTIS2023-506184-34-00
F. Hoffmann-La Roche AGAdvanced Malignancies
Start: 2019-08-09Target: 104Updated: 2025-11-10
Randomized, Multicenter, Phase III, Open-Label Study of Alectinib Versus Crizotinib In Treatment-Naive Anaplastic Lymphoma Kinase-Positive Advanced Non-Small Cell Lung Cancer
CompletedCTIS2023-506859-13-00
F. Hoffmann-La Roche AGAnaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC)
Start: 2014-09-09End: 2025-03-14Target: 51Updated: 2025-04-22
A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients with Resectable Stage I-III Non-Small Cell Lung Cancer, selected according to Biomarker Status
RecruitingCTIS2024-511239-91-00
F. Hoffmann-La Roche AGResectable Stage I-III Non-Small Cell Lung Cancer (NSCLC)
Start: 2025-05-05Target: 54Updated: 2025-11-10
A Phase 3 Study of the Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor NVL-655 Compared to Alectinib in First-Line Treatment of Patients With ALK-Positive Advanced Non-Small Cell Lung Cancer (ALKAZAR)
RecruitingCTIS2024-517553-26-00
Nuvalent Inc.Advanced ALK-positive non-small cell lung cancer (NSCLC)
Start: 2025-11-12Target: 291Updated: 2026-01-06

Phase 4

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