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AG-120

DRUG11 trials

Sponsors

Institut de Recherches Internationales Servier, Celgene, Groupe Francophone des Myelodysplasies, Stichting Hemato-Oncologie voor Volwassenen Nederland, Yale University

Conditions

AML Arising After Exposure to Genotoxic InjuryAML Arising From Antecedent Hematologic Disorder (AHD)AML Arising From Myelodysplastic Syndrome (MDS)Acute Myeloid LeukemiaAdvanced CholangiocarcinomaCholangiocarcinomaChondrosarcomaChondrosarcoma, Grade 2

Phase 1

Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation
RecruitingNCT02074839
Institut de Recherches Internationales ServierMyelodysplastic Syndromes, Other IDH1-mutated Positive Hematologic Malignancies, Relapsed or Refractory Acute Myeloid Leukemia (AML) +1
Start: 2014-03-01End: 2026-03-31Target: 291Updated: 2025-06-08
Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation
CompletedNCT02073994
Institut de Recherches Internationales ServierCholangiocarcinoma, Chondrosarcoma, Glioma +1
Start: 2014-03-01End: 2024-01-04Updated: 2026-02-17
Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation
Active, not recruitingNCT02632708
Institut de Recherches Internationales ServierAML Arising After Exposure to Genotoxic Injury, AML Arising From Antecedent Hematologic Disorder (AHD), AML Arising From Myelodysplastic Syndrome (MDS) +2
Start: 2015-12-31End: 2026-07-24Updated: 2025-04-11
A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy
Active, not recruitingNCT02677922
CelgeneLeukemia, Myeloid, Acute
Start: 2016-06-03End: 2026-09-30Updated: 2026-02-19
Study of AG-120 and AG-881 in Subjects With Low Grade Glioma
CompletedNCT03343197
Institut de Recherches Internationales ServierGlioma
Start: 2018-03-20End: 2025-03-28Updated: 2026-02-17

Phase 2

Phase 3

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