AG-120
Sponsors
Institut de Recherches Internationales Servier, Celgene, Groupe Francophone des Myelodysplasies, Stichting Hemato-Oncologie voor Volwassenen Nederland, Yale University
Conditions
AML Arising After Exposure to Genotoxic InjuryAML Arising From Antecedent Hematologic Disorder (AHD)AML Arising From Myelodysplastic Syndrome (MDS)Acute Myeloid LeukemiaAdvanced CholangiocarcinomaCholangiocarcinomaChondrosarcomaChondrosarcoma, Grade 2
Phase 1
Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation
RecruitingNCT02074839
Start: 2014-03-01End: 2026-03-31Target: 291Updated: 2025-06-08
Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation
CompletedNCT02073994
Start: 2014-03-01End: 2024-01-04Updated: 2026-02-17
Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation
Active, not recruitingNCT02632708
Start: 2015-12-31End: 2026-07-24Updated: 2025-04-11
A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy
Active, not recruitingNCT02677922
Start: 2016-06-03End: 2026-09-30Updated: 2026-02-19
Study of AG-120 and AG-881 in Subjects With Low Grade Glioma
CompletedNCT03343197
Start: 2018-03-20End: 2025-03-28Updated: 2026-02-17
Phase 2
IDH1 (AG 120) Inhibitor in Patients With IDH1 Mutated Myelodysplastic Syndrome
Active, not recruitingNCT03503409
Start: 2019-05-14End: 2027-04-02Target: 68Updated: 2025-05-18
A Study of the IDH1 Inhibitor AG-120 in Combination With the Checkpoint Blockade Inhibitor, Nivolumab, for Patients With IDH1 Mutated Relapsed/Refractory AML and High Risk MDS
WithdrawnNCT04044209
Start: 2020-02-12End: 2023-09-30Updated: 2022-01-20
AG-120 in People With IDH1 Mutant Chondrosarcoma
Active, not recruitingNCT04278781
Start: 2020-03-04End: 2026-03-31Updated: 2025-10-23
Phase 3
Study of AG-120 in Previously Treated Advanced Cholangiocarcinoma With IDH1 Mutations (ClarIDHy)
CompletedNCT02989857
Start: 2017-02-20End: 2021-05-17Updated: 2024-08-20
Study of AG-120 (Ivosidenib) vs. Placebo in Combination With Azacitidine in Participants With Previously Untreated Acute Myeloid Leukemia With an IDH1 Mutation
Active, not recruitingNCT03173248
Start: 2017-06-26End: 2026-06-30Updated: 2025-11-07
A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy
Active, not recruitingNCT03839771
Start: 2019-03-01End: 2034-09-19Target: 968Updated: 2024-10-02
Related Papers
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