Aflibercept Injection

DRUG17 trials

Sponsors

Instituto de Olhos de Goiania, Federation Francophone de Cancerologie Digestive, Maisonneuve-Rosemont Hospital, Centre Hospitalier Universitaire de Nice, Greater Houston Retina Research

Conditions

Age-Related Macular DegenerationChoroid DiseaseChoroidal NeovascularizationChoroidal Retinal NeovascularizationDiabetic Macular EdemaDiabetic Macular Edema (DME)Diabetic RetinopathyMetastatic Colorectal Cancer

Phase 1

Intense Treatment Regimen With Intravitreal Aflibercept Injection

Vitreous -Retina- Macula Consultants of New YorkNeovascular Age-Related Macular Degeneration

Start: 2018-09-11End: 2020-06-30Target: 30Updated: 2019-01-10

Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)

RecruitingNCT05769153

Alcon ResearchNeovascular Age-related Macular Degeneration (nAMD)

Start: 2023-12-06End: 2027-10-31Target: 140Updated: 2026-01-06

Phase 2

Efficacy and Safety of Aflibercept in Combination With FOLFIRI Chemotherapy as 1st Line Treatment for Patients With Metastatic Colorectal Cancer

CompletedNCT02181556

Federation Francophone de Cancerologie DigestiveMetastatic Colorectal Cancer

Start: 2014-10-31End: 2017-07-31Updated: 2021-06-07

Intravitreal Aflibercept as Indicated by Real-Time Objective Imaging to Achieve Diabetic Retinopathy Improvement

CompletedNCT03531294

Greater Houston Retina ResearchDiabetic Retinopathy

Start: 2018-05-23End: 2021-04-09Updated: 2021-05-21

The Sahlgrenska Anti-VEGF Study

Active, not recruitingNCT04101877

Vastra Gotaland RegionNeovascular Age-related Macular Degeneration

Start: 2020-09-03End: 2027-05-31Target: 402Updated: 2025-11-21

Study to Assess the Efficacy & Safety of KHK4951 in Patients With Diabetic Macular Edema

Active, not recruitingNCT06116916

Kyowa Kirin Co., Ltd.Diabetic Macular Edema (DME)

Start: 2024-01-09End: 2026-09-30Target: 150Updated: 2025-10-30

Study to Assess the Efficacy & Safety of KHK4951 in Patients With Neovascular Age-Related Macular Degeneration

Active, not recruitingNCT06116890

Kyowa Kirin Co., Ltd.Neovascular Age-Related Macular Degeneration (nAMD)

Start: 2024-01-31End: 2026-09-30Target: 180Updated: 2025-10-30

Phase 3

Prevention of Neovascular Glaucoma by Intravitreal Injections of Anti-VEGF in Patients Treated with Proton Therapy for a Large Choroidal Melanoma

CompletedNCT03172299

Centre Hospitalier Universitaire de NiceOcular Melanoma

Start: 2017-06-08End: 2025-01-31Updated: 2025-03-24

Adjunct Episcleral Brachytherapy for PCV

Not yet recruitingNCT05251636

Salutaris Medical Devices, Inc.Age-Related Macular Degeneration, Polypoid Choroidal Vasculopathy

Start: 2025-03-31End: 2028-09-30Target: 159Updated: 2023-08-30

Phase 4

Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization

Instituto de Olhos de GoianiaChoroidal Retinal Neovascularization

Start: 2013-10-31End: 2014-11-30Target: 20Updated: 2014-01-10

Effect of Aflibercept (Eylea®) in the Management of Bevacizumab (Avastin®) Resistant Diabetic Macular Edema

Maisonneuve-Rosemont HospitalDiabetic Macular Edema

Start: 2016-11-30End: 2017-11-30Target: 40Updated: 2017-03-27

Changes in Inflammatory Biomarkers Including Soluble CD14 and Hyperreflective Foci in DME Patients Treated With Aflibercept (FORESIGHT)

CompletedNCT03780361

Hyewon ChungDiabetic Macular Edema

Start: 2019-05-17End: 2024-02-01Updated: 2024-05-29

Aflibercept With and Without Micropulse Laser in Diabetic Macular Edema

CompletedNCT03866746

Al Hadi HospitalDiabetic Macular Edema

Start: 2017-05-08End: 2018-12-28Updated: 2019-07-05

Treat-and-extend Using Aflibercept for Type 3 Neovascularization

Kim's Eye HospitalRetinal Angiomatous Proliferation

Start: 2021-02-01End: 2024-08-20Target: 30Updated: 2022-08-22

Evaluation of the Retina in Patients With Non-proliferative Diabetic Retinopathy After Aflibercept Injection in the Eye

WithdrawnNCT04702048

University of RochesterRetinopathy, Diabetic

Start: 2021-02-01End: 2024-02-01Updated: 2021-05-05

Long-Term Efficacy and Safety of Intravitreal Aflibercept Injections for the Treatment of Diabetic Retinopathy for Subjects Who Completed the 2-Year PANORAMA Trial

CompletedNCT04708145

Greater Houston Retina ResearchDiabetic Retinopathy

Start: 2021-06-01End: 2024-07-31Updated: 2025-01-23

Unknown Phase

Treatment of Polypoidal Choroidal Vasculopathy in Pachychoroid

CompletedNCT04075188

Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone PalermoChoroidal Neovascularization, Choroid Disease

Start: 2017-09-18End: 2019-07-13Updated: 2019-09-03

Related Papers

Intravitreal Aflibercept for the Treatment of Diabetic Retinopathy Among Patients Who Completed PANORAMA: 1-Year Outcomes from the VOYAGE Extension Study.

2025-11-14

Longitudinal Quantitative Ultrawidefield Angiographic Features in Diabetic Retinopathy Treated with Aflibercept from the Intravitreal Aflibercept as Indicated by Real-Time Objective Imaging to Achieve Diabetic Retinopathy Improvement Trial.

2023-09-091 citations