Afamitresgene autoleucel

DRUG2 trials

Sponsors

Adaptimmune LLC, USWM CT, LLC

Conditions

Advanced Synovial SarcomaMalignant Peripheral Nerve Sheath Tumor (MPNST)Myxoid/Round Cell LiposarcomaNeuroblastoma (NBL)OsteosarcomaSynovial Sarcoma

Phase 1

SPEARHEAD-3 Pediatric Study

RecruitingNCT05642455

USWM CT, LLCMalignant Peripheral Nerve Sheath Tumor (MPNST), Neuroblastoma (NBL), Osteosarcoma +1

Start: 2023-09-01End: 2038-07-30Target: 20Updated: 2026-08-11

Phase 2

A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEAR™ T cells in subjects with Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma (SPEARHEAD 1 STUDY)

Active, not recruitingCTIS2024-512847-21-00

Adaptimmune LLCAdvanced Synovial Sarcoma, Myxoid/Round Cell Liposarcoma

Start: 2019-12-11Target: 48Updated: 2026-01-26

Related Papers

Efficacy and safety of engineered TCR-T cell therapy (afami-cel, lete-cel) in pediatric synovial sarcoma.

Journal of Clinical Oncology2026-05-27