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AEB071

DRUG15 trials

Sponsors

Novartis Pharmaceuticals, Novartis, Array Biopharma, now a wholly owned subsidiary of Pfizer, Columbia University

Conditions

CD79 Mutant or ABC-subtype Diffuse Large B-Cell LymphomaDiffuse Large B-Cell LymphomaHealthyKidney TransplantationModerate and Severe Plaque PsoriasisPanuveitisPosterior UveitisUlcerative Colitis

Phase 1

Efficacy and Safety of AEB071 Plus Tacrolimus (Converted to Mycophenolic Acid After 3 Months), in Renal Transplant Patients
CompletedNCT00403416
Novartis PharmaceuticalsKidney Transplantation
Start: 2006-10-31End: 2008-05-31Updated: 2020-12-17
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of AEB071
CompletedNCT00409929
NovartisHealthy
Start: 2006-06-30Updated: 2010-10-19
Safety of AEB071 in Healthy Volunteers and to Compare the Ethnicity, Metabolic, and Safety Effects Between Caucasian and Japanese Healthy Subjects
CompletedNCT00416546
NovartisHealthy
Start: 2006-10-31End: 2007-10-31Target: 96Updated: 2008-08-11
Efficacy and Safety of AEB071 Versus Tacrolimus in Combination With Mycophenolate Acid Sodium, Basiliximab and Steroids in Preventing Acute Rejection After Kidney Transplantation
CompletedNCT00492869
Novartis PharmaceuticalsKidney Transplantation
Start: 2007-01-31Updated: 2020-12-22
Pharmacokinetic Study of AEB071 in Patients Following Liver Transplantation
CompletedNCT00545259
Novartisde Novo Liver Transplantation
Start: 2007-10-31Updated: 2020-12-08
Study of AEB071 (a Protein Kinase C Inhibitor) in Patients With CD79-mutant Diffuse Large B-Cell Lymphoma
TerminatedNCT01402440
Novartis PharmaceuticalsDiffuse Large B-Cell Lymphoma
Start: 2011-11-30End: 2014-04-30Updated: 2020-12-19
Safety and Efficacy of AEB071 in Metastatic Uveal Melanoma Patients
CompletedNCT01430416
Novartis PharmaceuticalsUveal Melanoma
Start: 2011-12-20End: 2019-05-22Updated: 2020-12-19
A Phase Ib/II Study of AEB071 and MEK162 in Adult Patients With Metastatic Uveal Melanoma
TerminatedNCT01801358
Array Biopharma, now a wholly owned subsidiary of PfizerUveal Melanoma
Start: 2013-08-31End: 2015-05-31Updated: 2020-09-16
Safety and Efficacy of AEB071 and EVEROLIMUS in Patients With CD79-mutant or ABC Subtype Diffuse Large B-Cell Lymphoma
CompletedNCT01854606
Novartis PharmaceuticalsCD79 Mutant or ABC-subtype Diffuse Large B-Cell Lymphoma
Start: 2013-12-05End: 2016-06-01Updated: 2020-12-19
Trial of AEB071 in Combination With BYL719 in Patients With Melanoma
CompletedNCT02273219
Columbia UniversityUveal Melanoma
Start: 2014-11-19End: 2018-07-02Updated: 2023-08-15

Phase 2

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