AEB071
Sponsors
Novartis Pharmaceuticals, Novartis, Array Biopharma, now a wholly owned subsidiary of Pfizer, Columbia University
Conditions
CD79 Mutant or ABC-subtype Diffuse Large B-Cell LymphomaDiffuse Large B-Cell LymphomaHealthyKidney TransplantationModerate and Severe Plaque PsoriasisPanuveitisPosterior UveitisUlcerative Colitis
Phase 1
Efficacy and Safety of AEB071 Plus Tacrolimus (Converted to Mycophenolic Acid After 3 Months), in Renal Transplant Patients
CompletedNCT00403416
Start: 2006-10-31End: 2008-05-31Updated: 2020-12-17
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of AEB071
CompletedNCT00409929
Start: 2006-06-30Updated: 2010-10-19
Safety of AEB071 in Healthy Volunteers and to Compare the Ethnicity, Metabolic, and Safety Effects Between Caucasian and Japanese Healthy Subjects
CompletedNCT00416546
Start: 2006-10-31End: 2007-10-31Target: 96Updated: 2008-08-11
Efficacy and Safety of AEB071 Versus Tacrolimus in Combination With Mycophenolate Acid Sodium, Basiliximab and Steroids in Preventing Acute Rejection After Kidney Transplantation
CompletedNCT00492869
Start: 2007-01-31Updated: 2020-12-22
Pharmacokinetic Study of AEB071 in Patients Following Liver Transplantation
CompletedNCT00545259
Start: 2007-10-31Updated: 2020-12-08
Study of AEB071 (a Protein Kinase C Inhibitor) in Patients With CD79-mutant Diffuse Large B-Cell Lymphoma
TerminatedNCT01402440
Start: 2011-11-30End: 2014-04-30Updated: 2020-12-19
Safety and Efficacy of AEB071 in Metastatic Uveal Melanoma Patients
CompletedNCT01430416
Start: 2011-12-20End: 2019-05-22Updated: 2020-12-19
A Phase Ib/II Study of AEB071 and MEK162 in Adult Patients With Metastatic Uveal Melanoma
TerminatedNCT01801358
Start: 2013-08-31End: 2015-05-31Updated: 2020-09-16
Safety and Efficacy of AEB071 and EVEROLIMUS in Patients With CD79-mutant or ABC Subtype Diffuse Large B-Cell Lymphoma
CompletedNCT01854606
Start: 2013-12-05End: 2016-06-01Updated: 2020-12-19
Trial of AEB071 in Combination With BYL719 in Patients With Melanoma
CompletedNCT02273219
Start: 2014-11-19End: 2018-07-02Updated: 2023-08-15
Phase 2
Efficacy, Safety and Tolerability of AEB071 Versus Cyclosporine in the Novo Renal Transplant Recipients
CompletedNCT00504543
Start: 2007-07-31End: 2011-04-30Updated: 2016-11-18
24 Month Extension to Efficacy and Safety of AEB071 Plus Tacrolimus (Converted to Mycophenolic Acid After 3 Months) in Renal Transplant Patients(Converted to Mycophenolic Acid After 3 Months) in Renal Transplant Patients
TerminatedNCT00555789
Start: 2007-10-31End: 2008-03-31Updated: 2020-12-17
Efficacy, Safety and Tolerability of AEB071 in Patients With Active, Moderate to Severe Ulcerative Colitis
CompletedNCT00572585
Start: 2010-04-30End: 2012-04-30Updated: 2020-12-22
Safety, Tolerability, and Efficacy of AEB071 in the Treatment of Uveitis
CompletedNCT00615693
Start: 2008-07-31Updated: 2020-12-22
A Dose Finding Study of AEB071 Assessing Psoriasis Area and Severity Index in Patients With Plaque Psoriasis
CompletedNCT00885196
Start: 2009-04-30Updated: 2020-12-22