AdV-tk

BIOLOGICAL6 trials

Conditions

Anaplastic AstrocytomaGlioblastoma MultiformeGlioma, MalignantHepatocellular CarcinomaLiver CancerMalignant GliomaPancreatic AdenocarcinomaPancreatic Cancer

Phase 1

A Phase I Study of AdV-tk + Prodrug Therapy in Combination With Radiation Therapy for Pediatric Brain Tumors

CompletedNCT00634231

Candel Therapeutics, Inc.Malignant Glioma, Recurrent Ependymoma

Start: 2010-10-31End: 2021-06-30Updated: 2023-08-25

AdV-tk Therapy With Surgery and Chemoradiation for Pancreas Cancer (PaTK01)

CompletedNCT00638612

Candel Therapeutics, Inc.Pancreatic Adenocarcinoma, Pancreatic Cancer

Start: 2008-08-31End: 2015-06-30Updated: 2023-08-25

Phase 1b Study of AdV-tk + Valacyclovir Combined With Radiation Therapy for Malignant Gliomas

CompletedNCT00751270

Candel Therapeutics, Inc.Anaplastic Astrocytoma, Glioblastoma Multiforme, Malignant Glioma

Start: 2005-11-30End: 2011-01-31Updated: 2023-08-25

GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas

CompletedNCT03576612

Candel Therapeutics, Inc.Glioma, Malignant

Start: 2018-02-27End: 2023-06-30Updated: 2025-02-14

Phase 2

Preliminary Results for the Double-dose Adenovirus-mediated Adjuvant Therapy Improving Outcome of Liver Transplantation in Patients With Advanced Hepatocellular Carcinoma

CompletedNCT02202564

Huazhong University of Science and TechnologyHepatocellular Carcinoma, Liver Cancer

Start: 2006-10-31End: 2013-08-31Updated: 2014-07-29

Phase 3

Multicenter RCT of ADV-TK Gene Therapy Improving the Outcome of Liver Transplantation for Advanced HCC

NCT03313596

Huazhong University of Science and TechnologyHepatocellular Carcinoma

Start: 2013-03-31End: 2019-12-31Target: 180Updated: 2019-02-04

Related Papers

A multi-institutional phase 1 clinical trial exploring upfront multimodal standard of care and combined immunotherapies for newly diagnosed glioblastoma.

2025-10-013 citations

Combined cytotoxic and immune-stimulatory gene therapy using Ad-TK and Ad-Flt3L: Translational developments from rodents to glioma patients.

2023-08-1214 citations

1477 First efficacy and multi-omic analysis data from phase 1 clinical trial of oncolytic viral immunotherapy with CAN-2409 + valacyclovir in combination with nivolumab and standard of care in newly diagnosed high-grade glioma

2022-11-012 citations

Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma

Neuro-Oncology2019-03-1887 citations