Adjuvant Radiation Therapy

RADIATION3 trials

Sponsors

Abramson Cancer Center at Penn Medicine, Mayo Clinic, Alice Chung

Conditions

Axilla; BreastAxillary Nodal DiseaseBreast CancerFemale Breast CancerMastectomy; LymphedemaOropharyngeal CancerOropharynx CancerTumor, Breast

Phase 2

A Single-arm Phase II Study of Post-Transoral Robotic Surgery (TORS) Alone to the Primary Tumor Site and Selective Neck Dissection (SND) Followed by Adjuvant Radiation Therapy (+/- Chemotherapy) to the Regional Nodes for Advanced Stage, Human Papilloma Virus (HPV) Positive, Oropharyngeal Cancer

CompletedNCT02159703

Abramson Cancer Center at Penn MedicineOropharyngeal Cancer

Start: 2014-02-28End: 2018-02-28Updated: 2019-11-21

IIT2023-09-Chung-UpfrontTAD: Upfront TAD/SNB in Patients With Breast Cancer With Nodal Metastases

RecruitingNCT06092892

Alice ChungAxilla; Breast, Axillary Nodal Disease, Breast Cancer +3

Start: 2024-04-07End: 2031-04-01Target: 45Updated: 2026-08-10

Phase 3

Evaluation of De-escalated Adjuvant Radiation Therapy for Human Papillomavirus (HPV)-Associated Oropharynx Cancer

CompletedNCT02908477

Mayo ClinicOropharynx Cancer

Start: 2016-10-03End: 2024-11-15Updated: 2025-02-11

Related Papers

Abstract PS2-01-18: Targeted Axillary Dissection after Neoadjuvant Systemic Chemotherapy in patients with Early Breast Cancer: Estimating the Real-World Impact of Omitted Axillary Lymph Node Dissection using the Canto Cohort

Clinical Cancer Research2026-02-17

De-escalated adjuvant radiotherapy versus standard adjuvant treatment for human papillomavirus-associated oropharyngeal squamous cell carcinoma (MC1675): a phase 3, open-label, randomised controlled trial.

2025-09-015 citations

ctDNA and Recurrence Risk for Adjuvant De-Escalation in HPV-Positive Oropharyngeal Carcinoma: A Secondary Analysis of the DART Phase 3 Randomized Clinical Trial.

2025-07-016 citations