Adipose tissue is extirpated from patient with familial LCAT deficiency syndrome, and subjected to primary culture by ceiling culture. Normal LCAT gene is transduced into the obtained preadipocytes by

2 trials

Sponsors

Maezawa Yoshiro, Chiba university Chiba University hospital, Division of Diabetes, Metabolism and Endocrinology

Conditions

Familial LCAT deficiencyFamilial LCAT deficiency Corneal opacity, Renal dysfunction, Hemolytic anemia

Phase 2

The clinical study to evaluate the safety of the regenerative medicine and the gene therapy by the autologous transplantation of human LCAT gene transduced human pre-adipocyte

RecruitingJPRN-jRCT2033200096

Maezawa YoshiroFamilial LCAT deficiency Corneal opacity, Renal dysfunction, Hemolytic anemia

Start: 2020-08-25Target: 3Updated: 2026-06-29

Unknown Phase

Clinical research for auto-transplantation of lcat-gene transduced preadipocytes in patients with familial lecithin-cholesterol acyltransferase (LCAT) deficiency

RecruitingJPRN-UMIN000023810

Chiba university Chiba University hospital, Division of Diabetes, Metabolism and EndocrinologyFamilial LCAT deficiency

Start: 2016-09-01Target: 3Updated: 2026-06-29

Related Papers

LCAT-trial-24 weeks: Protocol for a clinical study to evaluate the safety of regenerative medicine and gene therapy by the autologous transplantation of human lecithin:cholesterol acyltransferase gene-transduced human pre-adipocytes

Contemporary Clinical Trials Communications2022-06-091 citations