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Ad-RTS-hIL-12

BIOLOGICAL6 trials

Sponsors

Alaunos Therapeutics

Conditions

Anaplastic OligoastrocytomaDiffuse Intrinsic Pontine GliomaGlioblastomaGlioblastoma MultiformeMetastatic Breast CancerPediatric Brain Tumor

Phase 1

A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma
CompletedNCT02026271
Alaunos TherapeuticsAnaplastic Oligoastrocytoma, Glioblastoma Multiforme
Start: 2015-06-30End: 2019-08-31Updated: 2025-04-16
A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Breast Cancer
TerminatedNCT02423902
Alaunos TherapeuticsMetastatic Breast Cancer
Start: 2015-07-18End: 2016-07-19Updated: 2025-08-28
A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG
TerminatedNCT03330197
Alaunos TherapeuticsDiffuse Intrinsic Pontine Glioma, Pediatric Brain Tumor
Start: 2017-09-26End: 2021-09-10Updated: 2025-08-12
A Study of Ad-RTS-hIL-12 With Veledimex in Combination With Nivolumab in Subjects With Glioblastoma; a Substudy to ATI001-102
CompletedNCT03636477
Alaunos TherapeuticsGlioblastoma
Start: 2018-06-18End: 2021-06-30Updated: 2025-08-12
Evaluation of Ad-RTS-hIL-12 + Veledimex in Subjects With Recurrent or Progressive Glioblastoma, a Substudy to ATI001-102
CompletedNCT03679754
Alaunos TherapeuticsGlioblastoma
Start: 2018-09-05End: 2021-01-19Updated: 2025-08-28

Phase 2

Study of Ad-RTS-hIL-12 + Veledimex in Combination With Cemiplimab in Subjects With Recurrent or Progressive Glioblastoma
TerminatedNCT04006119
Alaunos TherapeuticsGlioblastoma
Start: 2019-08-01End: 2021-08-05Updated: 2025-04-18

Related Papers

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Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial
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CTIM-20. FINAL RESULTS OF CONTROLLED IL-12 MONOTHERAPY AND IN COMBINATION WITH PD-1 INHIBITOR IN ADULT SUBJECTS WITH RECURRENT GLIOBLASTOMA
Neuro-Oncology2021-11-024 citations
CTIM-27. PHASE I/II STUDY OF CONTROLLED IL-12 AS IMMUNOTHERAPY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
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CTIM-28. PHASE 2 TRIAL OF CONTROLLED IL-12 IN COMBINATION WITH PD-1 INHIBITOR IN ADULT SUBJECTS WITH RECURRENT GLIOBLASTOMA (rGBM)
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CTIM-05. COMBINATION OF CONTROLLED INTERLEUKIN-12 GENE THERAPY WITH IMMUNE CHECKPOINT BLOCKADE IN RECURRENT GLIOBLASTOMA: UPDATED RESULTS OF A MULTI-INSTITUTIONAL, OPEN LABEL PHASE 1 TRIAL
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Final results of controlled IL-12 monotherapy in adults with grade III or IV gliomas.
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Demonstration of anti-tumor immunity via intratumoral regulated platform ad-RTS-hIL-12 in advanced breast cancer and recurrent glioblastoma patients.
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Expanded phase I study of intratumoral Ad-RTS-hIL-12 plus oral veledimex: Tolerability and survival in recurrent glioblastoma.
Journal of Clinical Oncology2017-05-208 citations
P06.09 In vitro assessment of human IL-12Fc function on porcine and canine peripheral blood mononuclear cells
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Effect of controlled intratumoral viral delivery of Ad-RTS-hIL-12 + oral veledimex in subjects with recurrent or progressive glioma.
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Phase 1b/2 study of intratumoral Ad-RTS-hIL-12 + veledimex in patients with chemotherapy-responsive locally advanced or metastatic breast cancer.
Journal of Clinical Oncology2016-05-20
Abstract OT1-01-05: Phase 1b/2 study of intratumoral Ad-RTS-hIL-12 + veledimex in patients with chemotherapy-responsive locally advanced or metastatic breast cancer
Cancer Research2016-02-15