Acthar

DRUG18 trials

Sponsors

Elliot Frohman, Phoenix Neurological Associates, LTD, Mallinckrodt, Dartmouth-Hitchcock Medical Center, Neuro-Ophthalmologic Associates, PC

Conditions

Amyotrophic Lateral SclerosisDecrease of Proteinuria With H.P. Acthar Gel and Its Effects on Clinical and Podocyte FunctionDermatomyositisFSGSKeratitisKidney DiseaseKidney TransplantationMembranous Nephropathy

Early Phase 1

Defining the Functional and Neuro-Protective Potential of ACTHAR in Acute Optic Neuritis

CompletedNCT01987167

Neuro-Ophthalmologic Associates, PCOptic Neuritis

Start: 2013-11-30End: 2016-12-31Updated: 2017-08-22

Phase 2

ACTHAR for Acute Treatment of Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate

TerminatedNCT01984268

Dartmouth-Hitchcock Medical CenterRheumatoid Arthritis

Start: 2014-06-23End: 2016-09-01Updated: 2021-01-15

Study of Acthar® Gel (Acthar) for Amyotrophic Lateral Sclerosis (ALS)

TerminatedNCT03068754

MallinckrodtAmyotrophic Lateral Sclerosis

Start: 2017-06-22End: 2019-11-25Updated: 2020-10-14

Phase 3

Use of Acthar in Patients With FSGS That Will be Undergoing Renal Transplantation

CompletedNCT02683889

University of Colorado, DenverFSGS

Start: 2019-02-01End: 2024-06-10Updated: 2026-03-23

Phase 4

Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis

TerminatedNCT00854750

Elliot FrohmanMultiple Sclerosis

Start: 2009-05-31End: 2010-07-31Updated: 2013-04-22

Acthar for the Treatment of Systemic Lupus Erythematosus (SLE) in Patients With a History of Persistently Active Disease

CompletedNCT01753401

MallinckrodtSystemic Lupus Erythematosus (SLE)

Start: 2013-01-31End: 2015-10-31Updated: 2020-02-27

Acthar as Rescue Therapy for Transplant Glomerulopathy in Kidney Transplant Recipients

TerminatedNCT02057523

University of Illinois at ChicagoProteinuria, Transplant Glomerulopathy

Start: 2014-09-30End: 2015-09-30Updated: 2020-09-04

Acthar for Treatment of Post-transplant FSGS

WithdrawnNCT02399462

University of North Carolina, Chapel HillFSGS, Kidney Transplantation, Renal Transplantation

Start: 2021-03-31End: 2021-07-31Updated: 2021-08-30

Use of Acthar in Rheumatoid Arthritis (RA) Related Flares

CompletedNCT02541955

Veena Ranganath, MD, MSRheumatoid Arthritis (RA)

Start: 2017-07-20End: 2025-05-20Updated: 2026-02-10

Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis

TerminatedNCT02769702

Washington University School of MedicineUveitis

Start: 2016-06-30End: 2017-01-06Updated: 2018-10-01

Effects of ACTHAR on Advanced MRI Surrogate Markers of Disease Activity and on Comprehensive Immune Signature During MS Relapses

TerminatedNCT03021317

University of ChicagoMultiple Sclerosis

Start: 2016-12-20End: 2020-10-07Updated: 2024-05-16

Adrenocorticotropic Hormone in Membranous Nephropathy

CompletedNCT03025828

Icahn School of Medicine at Mount SinaiMembranous Nephropathy

Start: 2018-03-19End: 2020-12-16Updated: 2022-08-15

Clinical Impact of Acthar in the Psoriatic Arthritis Patient (CLIPS)

CompletedNCT03419650

IRIS Research and Development, LLCPsoriatic Arthritis

Start: 2018-07-20End: 2021-08-25Updated: 2021-08-31

Impact of Acthar on Everyday Life of Participants With Severe Keratitis

CompletedNCT04169061

MallinckrodtKeratitis

Start: 2019-11-13End: 2020-12-07Updated: 2021-08-18

Unknown Phase

Dermatomyositis and Polymyositis Registry

Phoenix Neurological Associates, LTDDermatomyositis, Polymyositis

Start: 2013-04-30Target: 100Updated: 2015-11-06

ACTH Treatment of APOL1- Associated Nephropathy

WithdrawnNCT02006849

Wake Forest University Health SciencesKidney Disease

Start: 2014-01-31End: 2019-01-31Updated: 2017-11-07

Tolerability of Acthar for the Treatment of Multiple Sclerosis in Relapses (TAMS)

CompletedNCT02258217

OhioHealthRelapsing Remitting Multiple Sclerosis

Start: 2014-06-30End: 2016-12-31Updated: 2020-09-01

Experience With H.P. Acthar Gel Treatment of Patients With Nephrotic Syndrome/Proteinuria Due to Various Etiologies and Its Effect on Podocyte Function

Greater Boston Medical AssociatesDecrease of Proteinuria With H.P. Acthar Gel and Its Effects on Clinical and Podocyte Function

Start: 2017-01-25End: 2021-12-31Target: 40Updated: 2020-02-05

Related Papers

Repository Corticotropin Injection (Acthar® Gel) for Refractory Severe Noninfectious Keratitis: Efficacy and Safety from a Phase 4, Multicenter, Open-Label Study

Ophthalmology and Therapy2021-10-2012 citations

Efficacy and tolerability of repository corticotropin injection in patients with persistently active SLE: results of a phase 4, randomised, controlled pilot study

Lupus Science & Medicine2016-10-0131 citations