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Acoziborole

DRUG5 trials

Sponsors

Drugs for Neglected Diseases, Institute of Tropical Medicine, Belgium

Conditions

Gambiense TrypanosomiasisSleeping SicknessTrypanosoma Brucei Gambiense; InfectionTrypanosomiasis, AfricanTrypanosomiasis; African, Due to Trypanosoma Brucei Gambiense, Gambiense

Phase 1

DDI Study of Single Oral Dose of Acoziborole With Sequential Co-administration of Midazolam and Dextromethorphan
CompletedNCT05947604
Drugs for Neglected DiseasesTrypanosomiasis, African
Start: 2023-02-09End: 2023-05-03Updated: 2023-07-17

Phase 2

Efficacy and Safety of Acoziborole (SCYX-7158) in Patients With Human African Trypanosomiasis Due to T.b. Gambiense
CompletedNCT03087955
Drugs for Neglected DiseasesGambiense Trypanosomiasis, Sleeping Sickness, Trypanosomiasis, African
Start: 2016-10-11End: 2020-09-08Updated: 2025-09-17
Safety and Tolerability Study of Acoziborole in g-HAT Seropositive Subjects
CompletedNCT05256017
Drugs for Neglected DiseasesSleeping Sickness, Trypanosoma Brucei Gambiense; Infection, Trypanosomiasis, African
Start: 2021-12-30End: 2023-08-03Updated: 2025-03-20
Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients
CompletedNCT05433350
Drugs for Neglected DiseasesSleeping Sickness, Trypanosoma Brucei Gambiense; Infection, Trypanosomiasis, African
Start: 2022-07-09End: 2026-03-31Updated: 2026-04-06

Phase 3

Stop Transmission of Gambiense Human African Trypanosomiasis
RecruitingNCT07789743
Institute of Tropical Medicine, BelgiumTrypanosomiasis; African, Due to Trypanosoma Brucei Gambiense, Gambiense
Start: 2024-03-15End: 2027-12-30Target: 2500Updated: 2026-08-27

Related Papers

The STROGHAT study protocol: An intervention study to evaluate safety, effectiveness and feasibility of treating gambiense HAT seropositive subjects with acoziborole.
Open Research Europe2025-01-246 citations
Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single-arm, phase 2/3 trial.
2022-11-2965 citations
Trypanosome spliced leader RNA for diagnosis of acoziborole treatment outcome in gambiense human African trypanosomiasis: A longitudinal follow-up study.
2022-11-244 citations
Trypanosome SL-RNA detection in blood and cerebrospinal fluid to demonstrate active gambiense human African trypanosomiasis infection
PLoS neglected tropical diseases2021-09-1711 citations
Prescription of concomitant medications in patients treated with Nifurtimox Eflornithine Combination Therapy (NECT) for T.b. gambiense second stage sleeping sickness in the Democratic Republic of the Congo
PLoS neglected tropical diseases2020-01-2715 citations