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Acasunlimab

BIOLOGICAL10 trials

Sponsors

Genmab A/S, Genmab

Conditions

Advanced Endometrial CancerCutaneous MelanomaIIICLocally Advanced Unresectable Melanoma (Stage IIIBMalignant Solid Tumors - Non Small Cell Lung CancerMalignant solid tumors: endometrial carcinoma (EC)Metastatic Cutaneous Melanoma (Stage IV)Non Small Cell Lung Cancer Metastatic

Phase 1

Phase 2

Safety and Efficacy Study of GEN1046 as a Single Agent or in Combination With Pembrolizumab for Treatment of Recurrent (Non-small Cell) Lung Cancer
Active, not recruitingNCT05117242
GenmabNon Small Cell Lung Cancer Metastatic
Start: 2021-10-27End: 2027-05-27Updated: 2025-11-06
GEN1046 in Combination With Anticancer Agents for the Treatment of Advanced Endometrial Cancer
WithdrawnNCT06046274
GenmabAdvanced Endometrial Cancer
Start: 2023-10-01End: 2028-06-01Updated: 2024-04-30
A Phase 2, multicenter, randomized, open-label trial of GEN1046 as monotherapy and in combination with Pembrolizumab in subjects with relapsed/refractory metastatic non-small cell lung cancer after treatment with standard care therapy with a immune checkpoint inhibitor.
Active, not recruitingCTIS2024-513770-22-00
Genmab A/SMalignant Solid Tumors - Non Small Cell Lung Cancer
Start: 2021-09-22Target: 100Updated: 2025-09-30
Study of the Effectiveness and Safety of Acasunlimab Alone and With Pembrolizumab to Treat Advanced Melanoma of the Skin That Has Returned After Treatment With an Approved Checkpoint Inhibitor Therapy (ABBIL1TY MELANOMA-07)
Active, not recruitingNCT06984328
GenmabCutaneous Melanoma, Metastatic Cutaneous Melanoma (Stage IV), Relapsed/Refractory, Locally Advanced Unresectable Melanoma (Stage IIIB, IIIC, or IIID)
Start: 2025-07-25End: 2029-07-15Updated: 2026-03-03
Efficacy and Safety Study of Acasunlimab as Monotherapy and in Combination With Pembrolizumab in Subjects With Relapsed/Refractory, Unresectable Locally Advanced or Metastatic Cutaneous Melanoma That Progressed On or After Treatment With a Checkpoint Inhibitor
CompletedCTIS2025-520468-16-00
Genmab A/SCutaneous Melanoma, IIIC, Locally Advanced Unresectable Melanoma (Stage IIIB +3
End: 2026-01-19Target: 129Updated: 2025-10-27

Phase 3

Related Papers

Regular and Young Investigator Award Abstracts2022-11-011 citations