ABBV-400
Sponsors
AbbVie Deutschland GmbH & Co. KG, AbbVie
Conditions
Adenocarcinoma of the gastroesophageal junctionAdvanced Solid TumorsAdvanced or Metastatic Non-Squamous NSCLCBiliary Tract CancersColorectal CancerEsophageal Squamous Cell CarcinomaGastroesophageal AdenocarcinomaHead and Neck Squamous-Cell Carcinoma
Phase 1
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab
Active, not recruitingNCT05029882
Start: 2021-10-13End: 2027-11-30Updated: 2025-10-29
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
Active, not recruitingNCT06084481
Start: 2023-11-09End: 2026-07-01Updated: 2026-01-20
An Open-label Multi-Cohort Phase 1b/2 Study to Evaluate the Safety, Efficacy, and Optimal Dose of ABBV-400 in Combination with Budigalimab in Advanced or Metastatic Non-Squamous NSCLC with No Prior Treatment for Advanced Disease and No Actionable Genomic Alterations (AndroMETa-Lung-536)
RecruitingCTIS2024-514465-18-00
Start: 2025-04-23Target: 105Updated: 2025-11-27
Phase 2
Study to Assess Adverse Events and Change in Disease Activity in Previously Treated Adult Participants Receiving Intravenous (IV) ABBV-400 With Unresectable Metastatic Colorectal Cancer in Combination With IV Fluorouracil, Folinic Acid, and Bevacizumab
Active, not recruitingNCT06107413
Start: 2023-11-12End: 2026-12-31Target: 280Updated: 2025-12-12
A Phase 2, Randomized Study to Evaluate Safety, Efficacy, and Optimal Dose of ABBV-400 in Combination with Fluorouracil, Folinic Acid, and Bevacizumab and to Evaluate Safety and Efficacy of ABBV-400 in Combination with Bevacizumab in Previously Treated Subjects with Unresectable Metastatic Colorectal Cancer
Active, not recruitingCTIS2023-505110-14-00
Start: 2024-12-02Target: 61Updated: 2025-08-21
A Phase 2 Randomized Study to Evaluate the Safety, Efficacy, and Optimal Dose of Telisotuzumab Adizutecan in Combination with Fluorouracil, Leucovorin, and Budigalimab as First-Line Treatment in Subjects with Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (AndroMETa-GEA-977)
RecruitingCTIS2024-513008-32-00
Start: 2025-12-17Target: 50Updated: 2025-12-12