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DRUG20 trials

Sponsors

Hospices Civils De Lyon, Institut Gustave Roussy, Leiden University Medical Center, Stichting Radboud University Medical Center, Academisch Ziekenhuis Leiden

Conditions

BartonellosisChronic pulmonary aspergillosisFoot surgeryHand SurgeryHip or Knee prosthetic joint infection due to Staphylococcus aureusInflammation of sternal regionInflammatory response following human endotoxemia in healthy volunteersMenière's disease

Phase 2

Immunomodulatory effects of dexamethasone, tocilizumab and anakinra during experimental human endotoxemia: the DEDICATE-LPS study
Active, not recruitingCTIS2023-506556-24-00
Stichting Radboud University Medical CenterInflammatory response following human endotoxemia in healthy volunteers
Start: 2024-10-24Target: 52Updated: 2025-04-28
Evaluation of the benefit and safety of Localized Tissue Hydration (LTH) in the management of chronic common low back pain: Non-randomized single-center phase II study
Active, not recruitingCTIS2024-510625-25-00
Groupement De Cooperation Sanitaire Ramsay Generale De Sante Pour L'enseignement Et La Recherchechronic common low back pain
Start: 2024-11-14Target: 29Updated: 2025-02-28
PhagoDAIR I : A Pilot, Multicenter, Randomized, Non Comparative, Double-Blind Study of Phage Therapy in Patients with Hip or Knee Prosthetic Joint Infection due to Staphylococcus aureus Treated with DAIR and Antibiotic Therapy.
CompletedCTIS2024-516207-17-00
Phaxiam Therapeuticsknee or hip prosthetic joint infection (PJI) due to Staphylococcus aureus, with the indication of DAIR and Suppressive Antibiotics Therapy (SAT)
Start: 2022-06-15End: 2025-04-08Target: 29Updated: 2025-03-24
Patient reported efficacy of intranasal lysine-aspirin in controlling NSAID-exacerbated respiratory disease.
RecruitingCTIS2024-517437-40-00
UZ Leuven, UZ LeuvenNonsteroidal anti-inflammatory drug Exacerbated Respiratory Disease (N-ERD)
Start: 2022-11-15Target: 30Updated: 2024-10-25
CLEARTOX: Development of an innovative haemodialysis method to improve dialytic clearance of protein-bound uraemic toxins
RecruitingCTIS2023-510406-41-00
Hospices Civils De Lyonchronic hemodialysis patients (for more than 3 months) with no residual diuresis (<100 mL/day).
Start: 2025-09-22Target: 12Updated: 2025-06-04
A Phase II Proof of Concept Multicenter, Randomized, Double-Blind Study to assess the safety and efficacy of Phage Therapy in Patients with Hip or Knee Prosthetic Joint Infection due to Staphylococcus aureus Treated by DAIR
Not yet recruitingCTIS2024-516555-40-00
Phaxiam TherapeuticsHip or Knee prosthetic joint infection due to Staphylococcus aureus
Target: 51Updated: 2025-03-24
Efficacy and safety of allogenic cultured Adipose-derived mesenchymal stromal cell injections on MoUth fibrosis and handicap in patients with Systemic sclEroderma
Not yet recruitingCTIS2024-518516-39-00
Centre Hospitalier Universitaire De ToulouseSystemic sclEroderma
Target: 50Updated: 2025-08-01
Preoperative use of Romiplostim in thrombocytopenic patients undergoing cardiac surgery. A Phase 3, multicenter randomized double-blinded controlled against placebo study
Not yet recruitingCTIS2024-517710-15-00
Centre Hospitalier Universitaire De Nantesthrombocytopenic patients undergoing cardiac surgery
Target: 136Updated: 2025-12-15

Phase 3

Human recombinant interferon gamma in the treatment of ventilator-acquired pneumonia in ICU patients. IGNORANT study
RecruitingCTIS2022-502229-16-00
Hospices Civils De LyonVentilator acquired pneumonia
Start: 2023-06-19Target: 132Updated: 2025-08-25
A multicenter, double-blinded, randomized, placebo-controlled trial to compare the effectiveness of intratympanic injections methylPREDnisolone versus placebo in the treatment of vertigo attacks in MENière’s disease (PREDMEN trial).
RecruitingCTIS2023-503340-13-00
Leiden University Medical CenterMenière's disease
Start: 2023-10-05Target: 148Updated: 2024-11-18
tislelizUMaB in canceR patients with molEcuLar residuaL disease (UMBRELLA)
RecruitingCTIS2023-503316-33-00
Institut Gustave Roussypatients with a positive status for molecular residual disease (MRD) [MRD (+)] 2 to 5 months after the end of standard end of standard curative treatment
Start: 2024-09-26Target: 717Updated: 2025-10-21
PAmidronate for Pain in Sternocostoclavicular hyperostosis: the PAPS-study, a double-blind randomized placebo-controlled trial (PAPS)
RecruitingCTIS2023-510309-16-00
Academisch Ziekenhuis LeidenInflammation of sternal region, Sternocostoclavicular hyperostosis
Start: 2020-12-08Target: 70Updated: 2025-01-16
Interest of Intra-nodal injection of gentamicin for the treatment of suppurated cat scratch disease's lymphadenitis: a randomized controlled study. "BIGG" : Bartonellosis and intra-nodal injection of gentamicin
CompletedCTIS2024-512037-32-00
Centre Hospitalier Universitaire De ToulouseBartonellosis
Start: 2017-05-31End: 2025-08-21Target: 100Updated: 2024-10-16
Does high-dose vitamin B3 supplementation prevent major adverse kidney events during septic shock? A multicenter randomized controlled study.
CompletedCTIS2024-517055-13-00
Centre Hospitalier Universitaire Amiens Picardieadverse kidney events during septic shock
End: 2025-09-11Target: 310Updated: 2025-06-02
CPAAARI-Therapeutic efficacy comparison of a six-month treatment by itraconazole and nebulised Ambisome® versus treatment by itraconazole alone in non- or mildly- immunocompromised patients with Chronic Pulmonary Aspergillosis: a prospective, randomized, single blind study, (single aspergilloma excluded).
Not yet recruitingCTIS2024-517004-11-00
Centre Hospitalier Universitaire De PoitiersChronic pulmonary aspergillosis
Target: 224Updated: 2026-01-20
Rituximab therapy in anti-MAG patients with characteristics of good responders: THERAMAG study
Not yet recruitingCTIS2024-516335-27-00
Centre Hospitalier Universitaire De Saint Etienneanti-MAG neuropathy
Target: 90Updated: 2025-09-15
EFFICACY OF USUAL MANAGEMENT BY LOCAL ANESTHETIC INFILTRATION IN THE TREATMENT OF CHRONIC IDIOPATHIC ANO-PERINEAL PAIN: A RANDOMIZED DOUBLE-BLIND -CONTROLLED TRIAL
Not yet recruitingCTIS2024-518148-19-00
Groupe Hospitalier Diaconesses Croix Saint Simonchronic idiopathic ano-perineal pain
Target: 60Updated: 2024-12-11
The effect of a superficial parasternal intercostal plane block in cardiac surgical patients undergoing conventional median sternotomy: a multicentric, double-blind, prospective, randomized controlled superiority trial.
RecruitingCTIS2025-522135-34-00
UZ LeuvenPatients undergoing cardiac surgery through conventional median sternotomy access
Start: 2025-11-14Target: 136Updated: 2025-10-01

Phase 4

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