5-HT3 antagonist

DRUG4 trials

Sponsors

National Cancer Institute (NCI), Merck Sharp & Dohme LLC, toqa saad mohammed mohammed

Conditions

Chemotherapy-induced Nausea and VomitingColorectal CancerGranulosa Cell Ovarian CancerLymphomasMetastatic Colon CarcinomaNSCLCSolid Tumors

Phase 1

TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas

CompletedNCT01851369

National Cancer Institute (NCI)Granulosa Cell Ovarian Cancer, Lymphomas, Metastatic Colon Carcinoma +2

Start: 2013-07-12End: 2023-08-01Updated: 2024-05-08

The Role of Coenzyme Q10 in the Prophylaxis of Oxaliplatin Induced Peripheral Neuropathy in Patients With Colorectal Cancer

RecruitingNCT06856447

toqa saad mohammed mohammedColorectal Cancer

Start: 2024-06-01End: 2026-01-10Target: 22Updated: 2025-03-04

Phase 3

Efficacy and Safety Study of Fosaprepitant (MK-0517) Plus Ondansetron Versus Ondansetron Alone for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Participants (MK-0517-044)

TerminatedNCT02519842

Merck Sharp & Dohme LLCChemotherapy-induced Nausea and Vomiting

Start: 2015-09-14End: 2017-02-24Updated: 2019-03-15

Phase 4

Safety of a Three-Day Fosaprepitant Regimen for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Participants (MK-0517-045)

CompletedNCT04054193

Merck Sharp & Dohme LLCChemotherapy-induced Nausea and Vomiting

Start: 2019-09-09End: 2021-02-11Updated: 2025-01-16

Related Papers

Phase 2 trial of TRC102 (methoxyamine HCl) with temozolomide (TMZ) in patients with granulosa cell ovarian cancer.

Journal of Clinical Oncology2023-06-011 citations

Abstract LB-293: A Phase II trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed metastatic colorectal carcinoma

Cancer Research2019-07-011 citations

Abstract LB-293: A Phase II trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed metastatic colorectal carcinoma

Molecular and Cellular Biology / Genetics2019-07-01

A phase I trial of TRC102 (methoxyamine HCl) with temozolomide (TMZ) in patients with solid tumors and lymphomas.

Journal of Clinical Oncology2017-05-201 citations

A phase 1 trial of TRC102 (methoxyamine HCl) with temozolomide (TMZ) in patients with solid tumors and lymphomas.

Journal of Clinical Oncology2016-05-204 citations