5-FU medac 50 mg/ml
Sponsors
Leap Therapeutics Inc., Janssen - Cilag International, Enliven Therapeutics Inc., Goethe University Frankfurt, Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbH
Conditions
Advanced or Metastatic Colorectal CancerColorectal Cancer and Breast CancerColorectal cancerGastric AdenocarcinomaGastric cancerGastroEsophageal CancerHER2 positive resectable esophagogastric adenocarcinomaHER2-positive
Phase 1
A Phase 1b/2, Open-Label Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants with Advanced or Metastatic Colorectal Cancer
RecruitingCTIS2023-506517-22-00
Start: 2022-08-31Target: 37Updated: 2025-12-12
A Phase 1a/1b Study of ELVN-002 Combined with Trastuzumab in Advanced Stage HER2+ Solid tumors, and ELVN-002 Combined with Trastuzumab and Chemotherapy in Advanced Stage HER2+ Colorectal Cancer and Breast Cancer
Active, not recruitingCTIS2023-509716-29-00
Start: 2024-09-23Target: 156Updated: 2025-11-24
NEOadjuvant chemotherapy only compared with standard treatment for Locally Advanced Rectal cancer: a randomized phase II trial
Active, not recruitingCTIS2024-517748-76-00
Start: 2016-11-14Target: 124Updated: 2024-10-08
NeoART – A phase Ib/II platform trial evaluating the safety and activity of neoadjuvant trastuzumab-deruxtecan containing combination therapies for HER2+, resectable esophagogastric adenocarcinoma
RecruitingCTIS2024-518841-12-00
Start: 2025-03-25Target: 39Updated: 2025-12-01
A Phase 1b/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5764227 in combination with Standard of Care (SoC) or other agents in Participants with Advanced Solid Tumors
RecruitingCTIS2025-522274-37-00
Start: 2025-12-03Target: 15Updated: 2025-11-21
Phase 2
A Phase 2, Multicenter, Open-Label Study of DKN-01 in Combination with Tislelizumab ± Chemotherapy as First-Line or Second-Line Therapy in Adult Patients with Inoperable, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (DisTinGuish)
CompletedCTIS2023-504940-32-00
Start: 2023-10-13End: 2025-02-17Target: 15Updated: 2024-09-26
The PRESTO Trial - Organ preservation with durvalumab-based immunotherapy in combination with chemoradiation as definitive therapy for early stage, cT1 and cT2N0, esophageal adenocarcinoma with indication for radical surgery: A prospective, multicenter study of the FLOT-AIO Gastric Cancer Group
RecruitingCTIS2024-512980-29-00
Start: 2023-08-28Target: 32Updated: 2025-10-22
DANTE / FLOT8
A randomized, open-label Phase II/III efficacy and safety study of atezolizumab in combination with FLOT versus FLOT alone in patients with gastric cancer and adenocarcinoma of the oesophago-gastric junction and high immune responsiveness (MO30039/MO43340)– The IKF-DANTE Trial
A Trial of AIO in collaboration with SAKK
Active, not recruitingCTIS2024-514945-12-00
Start: 2018-09-03Target: 624Updated: 2025-12-11
Organ preservation in locally advanced rectal cancer by
radiochemotherapy followed by consolidation chemotherapy. A
prospective phase II pilot trial of the German Rectal Cancer
Study Group
CompletedCTIS2024-517928-19-00
Start: 2018-04-17End: 2025-07-30Target: 89Updated: 2025-02-25
Pembrolizumab and trastuzumab in combination with FLOT in the perioperative treatment of HER2-positive, localized esophagogastric adenocarcinoma - A phase II trial of the AIO study group – PHERFLOT
Active, not recruitingCTIS2024-513610-34-00
Start: 2023-02-13Target: 30Updated: 2025-06-30
FUTURE platform trial –
A phase II platform trial of futibatinib in combination with (chemo)immunotherapy in colorectal cancer and other solid tumor entities
RecruitingCTIS2024-517573-24-00
Start: 2025-12-08Target: 33Updated: 2025-12-02
Phase 3
Short course radiotherapy versus chemoradiotherapy, followed by consolidation chemotherapy, and selective organ preservation for MRI-defined intermediate and high-risk rectal cancer patients, A randomized phase III trial of the German Rectal Cancer Study Group
Active, not recruitingCTIS2024-511577-29-01
Start: 2020-03-13Target: 688Updated: 2026-01-26
Ramucirumab plus Irinotecan / Leucovorin / 5-FU versus Ramucirumab plus Paclitaxel in patients with advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction, who failed one prior line of palliative chemotherapy - The Phase II/III RAMIRIS STUDY
Active, not recruitingCTIS2024-512934-14-00
Start: 2016-11-07Target: 319Updated: 2025-06-23
A Phase 3 Multicenter, Randomized, Open-label Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab Versus Standard of Care in the First-line Treatment of Patients With Locoregional Recurrence of Squamous Cell Carcinoma of the Head and Neck (HNSCC) With No Distant Metastases
Not yet recruitingCTIS2025-523017-28-00
Target: 30Updated: 2026-04-03