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5-FU medac 50 mg/ml

DRUG14 trials

Sponsors

Leap Therapeutics Inc., Janssen - Cilag International, Enliven Therapeutics Inc., Goethe University Frankfurt, Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbH

Conditions

Advanced or Metastatic Colorectal CancerColorectal Cancer and Breast CancerColorectal cancerGastric AdenocarcinomaGastric cancerGastroEsophageal CancerHER2 positive resectable esophagogastric adenocarcinomaHER2-positive

Phase 1

A Phase 1b/2, Open-Label Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants with Advanced or Metastatic Colorectal Cancer
RecruitingCTIS2023-506517-22-00
Janssen - Cilag InternationalAdvanced or Metastatic Colorectal Cancer
Start: 2022-08-31Target: 37Updated: 2025-12-12
A Phase 1a/1b Study of ELVN-002 Combined with Trastuzumab in Advanced Stage HER2+ Solid tumors, and ELVN-002 Combined with Trastuzumab and Chemotherapy in Advanced Stage HER2+ Colorectal Cancer and Breast Cancer
Active, not recruitingCTIS2023-509716-29-00
Enliven Therapeutics Inc.Colorectal Cancer and Breast Cancer, Solid Tumors
Start: 2024-09-23Target: 156Updated: 2025-11-24
NEOadjuvant chemotherapy only compared with standard treatment for Locally Advanced Rectal cancer: a randomized phase II trial
Active, not recruitingCTIS2024-517748-76-00
Region SjaellandRectum cancer
Start: 2016-11-14Target: 124Updated: 2024-10-08
NeoART – A phase Ib/II platform trial evaluating the safety and activity of neoadjuvant trastuzumab-deruxtecan containing combination therapies for HER2+, resectable esophagogastric adenocarcinoma
RecruitingCTIS2024-518841-12-00
Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbHHER2 positive resectable esophagogastric adenocarcinoma
Start: 2025-03-25Target: 39Updated: 2025-12-01
A Phase 1b/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5764227 in combination with Standard of Care (SoC) or other agents in Participants with Advanced Solid Tumors
RecruitingCTIS2025-522274-37-00
Glaxosmithkline Research & Development LimitedNeoplasms
Start: 2025-12-03Target: 15Updated: 2025-11-21

Phase 2

A Phase 2, Multicenter, Open-Label Study of DKN-01 in Combination with Tislelizumab ± Chemotherapy as First-Line or Second-Line Therapy in Adult Patients with Inoperable, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (DisTinGuish)
CompletedCTIS2023-504940-32-00
Leap Therapeutics Inc.Gastric Adenocarcinoma, Gastric cancer, GastroEsophageal Cancer
Start: 2023-10-13End: 2025-02-17Target: 15Updated: 2024-09-26
The PRESTO Trial - Organ preservation with durvalumab-based immunotherapy in combination with chemoradiation as definitive therapy for early stage, cT1 and cT2N0, esophageal adenocarcinoma with indication for radical surgery: A prospective, multicenter study of the FLOT-AIO Gastric Cancer Group
RecruitingCTIS2024-512980-29-00
Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbHT1-T2N0 esophageal adenocarcinoma including gastroesophageal junction (GEJ) with indication for radical surgery
Start: 2023-08-28Target: 32Updated: 2025-10-22
DANTE / FLOT8 A randomized, open-label Phase II/III efficacy and safety study of atezolizumab in combination with FLOT versus FLOT alone in patients with gastric cancer and adenocarcinoma of the oesophago-gastric junction and high immune responsiveness (MO30039/MO43340)– The IKF-DANTE Trial A Trial of AIO in collaboration with SAKK
Active, not recruitingCTIS2024-514945-12-00
Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbHlocally advanced resectable adenocarcinoma of the oesophagogastric junction or the stomach
Start: 2018-09-03Target: 624Updated: 2025-12-11
Organ preservation in locally advanced rectal cancer by radiochemotherapy followed by consolidation chemotherapy. A prospective phase II pilot trial of the German Rectal Cancer Study Group
CompletedCTIS2024-517928-19-00
Universitaetsklinikum Tuebingen AöRMale and female patients with histologically confirmed diagnosis of rectal cancer
Start: 2018-04-17End: 2025-07-30Target: 89Updated: 2025-02-25
Pembrolizumab and trastuzumab in combination with FLOT in the perioperative treatment of HER2-positive, localized esophagogastric adenocarcinoma - A phase II trial of the AIO study group – PHERFLOT
Active, not recruitingCTIS2024-513610-34-00
Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbHHER2-positive, localized esophagogastric adenocarcinoma
Start: 2023-02-13Target: 30Updated: 2025-06-30
FUTURE platform trial – A phase II platform trial of futibatinib in combination with (chemo)immunotherapy in colorectal cancer and other solid tumor entities
RecruitingCTIS2024-517573-24-00
Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbHColorectal cancer
Start: 2025-12-08Target: 33Updated: 2025-12-02

Phase 3