5-FLUOROURACIL–EBEWE

DRUG2 trials

Sponsors

1globe Health Institute LLC, Glaxosmithkline Research & Development Limited

Conditions

Histologically confirmed adenocarcinoma of the colon or rectum that is metastatic.Neoplasms

Phase 1

A Phase 1b/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5764227 in combination with Standard of Care (SoC) or other agents in Participants with Advanced Solid Tumors

RecruitingCTIS2025-522274-37-00

Glaxosmithkline Research & Development LimitedNeoplasms

Start: 2025-12-03Target: 15Updated: 2025-11-21

Phase 3

A Phase III, Randomized, Open-Label Clinical Study of Napabucasin in Combination with FOLFIRI and Best Supportive Care (BSC) Versus Napabucasin plus BSC in Adult Patients with Previously Treated Metastatic Colorectal Cancer (CRC)

Active, not recruitingCTIS2024-518204-50-00

1globe Health Institute LLCHistologically confirmed adenocarcinoma of the colon or rectum that is metastatic.

Start: 2022-04-25Target: 123Updated: 2025-12-10