5-aminolevulinic acid

DRUG15 trials

Sponsors

Miyakawa University Jinpei, Kyoto Prefectural University of Medicine, kawasaki medical school, Kansai Medical University, David W. Roberts

Conditions

5-aminolevulinic AcidAstrocytomaBladder tumor in elderly patients with renal impairment bladder tumorBrain NeoplasmsBrain TumorBrain TumorsBreast cancerCrohn Disease

Phase 1

Fluorescence Guided Resection of Brain Tumors

CompletedNCT00870779

David W. RobertsBrain Tumors

Start: 2007-05-31End: 2013-07-02Updated: 2019-06-14

A Study of the Specificity and Sensitivity of 5-ALA Fluorescence in Malignant Brain Tumors

WithdrawnNCT00977795

Endeavor HealthBrain Neoplasms

Start: 2009-09-30End: 2010-01-31Updated: 2019-09-10

Phase I Study of Orally Administered Aminolevulinic Acid for Resection of Malignant Astrocytomas

TerminatedNCT01502605

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsAstrocytoma, Glioma

Start: 2012-09-30End: 2016-06-30Updated: 2017-01-05

ALA-induced PpIX Fluorescence During Brain Tumor Resection

Active, not recruitingNCT02191488

David W. RobertsBrain Tumors

Start: 2014-07-01End: 2028-12-31Target: 540Updated: 2026-07-29

Development of New Diagnostic Method of Sentinel Lymph Nodes and Surgical Margins Using 5-Aminolevulinic Acid in Breast Cancer Patients.

Active, not recruitingJPRN-UMIN000018386

Kyoto Prefectural University of MedicineBreast cancer

Start: 2015-08-01Target: 130Updated: 2026-06-29

Development of New Diagnostic Method for Lymph Nodes Using 5-Aminolevulinic Acid in Uterine endometrial Patients.

Active, not recruitingJPRN-UMIN000023436

Kyoto Prefectural University of MedicineUterine endometrial cancer

Start: 2016-10-01Target: 15Updated: 2026-06-29

Extracorporeal Photopheresis of Patients With Crohn's Disease Using 5-aminolevulinic Acid

CompletedNCT04164849

University Hospital, AkershusCrohn Disease

Start: 2019-11-22End: 2023-10-31Updated: 2024-01-30

Phase 2

PD L 506 for Stereotactic Interstitial Photodynamic Therapy of Newly Diagnosed Supratentorial IDH Wild-type Glioblastoma

TerminatedNCT03897491

photonamic GmbH & Co. KGGlioblastoma

Start: 2021-09-03End: 2026-04-08Updated: 2026-06-01

Sonodynamic Therapy with ExAblate System in Glioblastoma Patients

CompletedNCT04845919

Fondazione I.R.C.C.S. Istituto Neurologico Carlo BestaGlioblastoma Multiforme

Start: 2023-02-22End: 2024-10-30Updated: 2024-11-12

Safety Study of Reduced-Dose 5-Aminolevulinic Acid Administration in Elderly Patients with Renal Impairment

RecruitingJPRN-jRCTs031250795

Miyakawa University JinpeiBladder tumor in elderly patients with renal impairment bladder tumor

Start: 2026-03-11Target: 30Updated: 2026-06-29

Phase 3

Phase III Clinical Trial Evaluating the Resection Efficacy of 5-Aminolevulinic Acid Hydrochloride (5-ALA HCl) Fluorescence-Guided Microsurgery Versus Conventional White Light Microsurgery in Patients With Malignant Glioma (WHO Grade 3/4)

RecruitingNCT06160492

Lee's Pharmaceutical Limited5-aminolevulinic Acid, Fluorescence-guided Resection

Start: 2025-04-14End: 2026-03-31Target: 144Updated: 2025-05-13

Unknown Phase

Clinical evaluation of 5-ALA/SFC for cisplatin induced renal injury

Active, not recruitingJPRN-UMIN000024642

kawasaki medical schoolUnresectable gastric cancer

Start: 2014-07-01Target: 40Updated: 2026-06-29

Examination of the 5-ALA clinical application for gynecologic malignant tumor

RecruitingJPRN-UMIN000029400

Kansai Medical UniversityEndometrial cancer, ovarian tumor

Start: 2017-10-03Target: 10Updated: 2026-06-29

Novel Exoscope System for 5-ALA Fluorescence-Guided Surgery for Gliomas

CompletedNCT04055688

H. Lee Moffitt Cancer Center and Research InstituteBrain Tumor, Glioma

Start: 2019-08-15End: 2021-02-23Updated: 2022-05-31

A Pilot Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Pituitary Adenomas

Massachusetts General HospitalPituitary Adenoma

Start: 2021-07-31End: 2021-12-31Target: 40Updated: 2021-02-24

Related Papers

Oral 5-aminolevulinic Acid for Patients With Localized Prostate Cancer Undergoing Low-dose-rate Brachytherapy: AMBER Trial.

2024-11-012 citations

A prospective study of oral 5-aminolevulinic acid to prevent adverse events in patients with localized prostate cancer undergoing low-dose-rate brachytherapy: Protocol of the AMBER study.

2020-06-173 citations

Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection

Journal of neurosurgery2017-08-0460 citations