5 mg comprimidos recubiertos con película EFG
Sponsors
Fundacion Para La Formacion E Investigacion Sanitaria De La Region De Murcia, Medica Scientia Innovation Research S.L., Fundacion Publica Galega Instituto De Investigacion Sanitaria De Santiago De Compostela
Conditions
Active smokersHER2- positive breast cancerHeart FailureStudy to evaluate the effect of metformin in the prevention of hyperglycemia
in HR[+]/HER2[–] PIK3CA-mutated advanced breast cancer patients treated
with alpelisib plus endocrine therapy. The Metallica study.Unresectable locally recurrent or metastatic hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-low/ultralow breast cancer classified as non-luminal by gene expression profiling.
Phase 2
Study to evaluate the effect of metformin in the prevention of hyperglycemia
in HR[+]/HER2[–] PIK3CA-mutated advanced breast cancer patients treated
with alpelisib plus endocrine therapy. The Metallica study.
CompletedCTIS2024-511295-33-00
Start: 2020-08-13End: 2025-03-16Target: 88Updated: 2025-02-03
Chemotherapy-free trastuzumab and pertuzumab in HER2-positive breast cancer: FDG-PET response-adapted strategy
The PHERGain study.
Active, not recruitingCTIS2023-509923-42-00
Start: 2017-07-06Target: 345Updated: 2025-11-25
A randomized phase II study to evaluate the safety and efficacy of trastuzumab deruxtecan versus CDK4/6 inhibitor-based endocrine therapy as first-line therapy of HR-positive and HER2-low/ultra-low advanced breast cancer patients classified as non-luminal subtype according to gene expression profiling (The PONTIAC Study).
RecruitingCTIS2024-512360-55-00
Start: 2025-06-30Target: 194Updated: 2026-01-16
Phase 4
Withdrawal of Pharmacological Treatment in Patients Responding to Cardiac Resynchronization Therapy: (REMOVE)
Active, not recruitingCTIS2023-504946-70-00
Start: 2021-12-01Target: 60Updated: 2024-05-20
Phase IV, randomized, open-label, open-label, controlled, parallel, multicenter clinical trial in patients who are candidates for smoking cessation to evaluate the safety and efficacy of citisinicline maintenance therapy.
RecruitingCTIS2024-518936-36-00
Start: 2026-01-23Target: 400Updated: 2025-08-21