3BNC117-LS
Sponsors
Imperial College London Limited, ANRS Maladies Infectieuses Emergentes, Rockefeller University, National Institute of Allergy and Infectious Diseases (NIAID), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Conditions
HIVHIV InfectionsHIV-1HIV-1-infectionHuman Immunodeficiency Virus
Phase 1
3BNC117-LS First-in-Human Phase 1 Study
CompletedNCT03254277
Start: 2017-09-13End: 2020-12-31Updated: 2021-02-03
First-in-human Study of 10-1074-LS Alone and in Combination With 3BNC117-LS
CompletedNCT03554408
Start: 2018-06-20End: 2021-02-04Updated: 2021-08-04
3BNC117-LS and 10-1074-LS in Viremic HIV-infected Individuals
CompletedNCT04250636
Start: 2020-10-13End: 2022-02-11Updated: 2023-06-26
Broadly Neutralizing Antibodies 3BNC117-LS & 10-1074-LS to Prevent Relapse During ATI
WithdrawnNCT05079451
Start: 2024-01-01End: 2024-02-15Updated: 2023-09-07
3BNC117-LS and 10-1074-LS Plus N-803 (bNAb+N-803)
CompletedNCT05245292
Start: 2022-12-07End: 2025-12-31Updated: 2026-03-31
A Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living With HIV and on Suppressive Antiretroviral Therapy
Active, not recruitingNCT05612178
Start: 2023-07-26End: 2027-03-31Updated: 2026-03-16
Phase 2
Antiretrovirals Combined With Antibodies for HIV-1 Cure In Africa
RecruitingNCT06205602
Start: 2025-01-17End: 2029-02-16Target: 135Updated: 2025-01-31
A randomised phase II placebo-controlled trial of ART plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) vs ART plus placebo during primary HIV-1 infection to study the impact on post-treatment HIV control
RecruitingCTIS2024-516150-22-00
Start: 2024-04-11Target: 69Updated: 2025-10-01
The RIO Trial: A randomised placebo controlled trial of ART plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) vs ART plus placebo in treated Primary or Early stage HIV Infection on viral control off ART
RecruitingCTIS2024-514564-13-00
Start: 2025-01-02Target: 21Updated: 2025-11-21