3,4-Methylenedioxymethamphetamine

DRUG17 trials

Sponsors

University Hospital, Basel, Switzerland, Parc de Salut Mar, University of Chicago, VA Loma Linda Health Care System, Germans Trias i Pujol Hospital

Conditions

Amphetamine-Related DisordersChronic Neuropathic PainCombat Stress DisordersHealthyHealthy SubjectsMDMA ('Ecstasy')Mood DisorderPost Traumatic Stress Disorder

Early Phase 1

Effects of MDMA and Methylphenidate on Social Cognition

CompletedNCT01616407

University Hospital, Basel, SwitzerlandSocial Cognition

Start: 2012-08-31End: 2013-04-30Updated: 2018-12-11

Phase 1

Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy)

CompletedNCT00990067

University Hospital, Basel, SwitzerlandAmphetamine-Related Disorders, Mood Disorder, Substance-Related Disorders

Start: 2009-11-30End: 2010-05-31Updated: 2013-01-25

Pharmacological Interaction Between Clonidine and Methylenedioxymethamphetamine (MDMA)

CompletedNCT01136278

University Hospital, Basel, SwitzerlandAmphetamine-Related Disorders, Mood Disorder, Substance-Related Disorders

Start: 2010-07-31End: 2010-12-31Updated: 2013-01-25

Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA)

CompletedNCT01386177

University Hospital, Basel, SwitzerlandAmphetamine-Related Disorders, Mood Disorder, Substance-Related Disorders

Start: 2011-07-31End: 2012-01-31Updated: 2018-12-11

Emotional Effects of Methylphenidate and MDMA in Healthy Subjects

CompletedNCT01465685

University Hospital, Basel, SwitzerlandHealthy

Start: 2011-12-31End: 2013-01-31Updated: 2016-01-21

Abuse Liability and Human Pharmacology of Mephedrone

CompletedNCT02232789

Parc de Salut MarAmphetamine-Related Disorders

Start: 2014-09-30End: 2014-12-31Updated: 2014-12-04

Effect of Stimulant Drugs on Social Perception

CompletedNCT03790618

University of ChicagoHealthy, MDMA ('Ecstasy')

Start: 2016-06-01End: 2018-08-01Updated: 2024-01-05

Effects of MDMA Co-administration on the Response to LSD in Healthy Subjects

CompletedNCT04516902

University Hospital, Basel, SwitzerlandHealthy

Start: 2021-01-01End: 2022-08-22Updated: 2022-08-23

Effects of MDMA-like Substances in Healthy Subjects

CompletedNCT04847206

University Hospital, Basel, SwitzerlandHealthy

Start: 2021-12-01End: 2024-06-18Updated: 2024-08-14

Acute Effects of R- and S-MDMA in Healthy Subjects

CompletedNCT05277636

University Hospital, Basel, SwitzerlandHealthy

Start: 2022-10-01End: 2024-01-13Updated: 2024-01-17

Abuse Potential and Human Pharmacology of Methylone

Germans Trias i Pujol HospitalHealthy Subjects, Substance Use

Start: 2021-12-01End: 2022-09-30Updated: 2022-08-08

Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects

CompletedNCT05523401

University Hospital, Basel, SwitzerlandHealthy

Start: 2023-08-16End: 2024-11-05Updated: 2025-03-05

Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy Subjects

RecruitingNCT06884514

University Hospital, Basel, SwitzerlandHealthy

Start: 2025-04-03End: 2026-07-01Target: 24Updated: 2025-05-21

Phase 2

MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD

CompletedNCT04264026

VA Loma Linda Health Care SystemCombat Stress Disorders, Post Traumatic Stress Disorder

Start: 2021-07-29End: 2025-05-01Updated: 2025-07-20

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

RecruitingNCT05790239

Stephen Robert MarderPost Traumatic Stress Disorder

Start: 2025-03-01End: 2026-03-31Target: 40Updated: 2025-03-28

Ecstasy to Alleviate SEvere Chronic Neuropathic Pain Trial

RecruitingNCT07301632

Unity Health TorontoChronic Neuropathic Pain

Start: 2026-01-30End: 2028-12-01Target: 40Updated: 2026-02-13

Unknown Phase

Pharmacological Interaction Between Carvedilol and Methylenedioxymethamphetamine (MDMA)

CompletedNCT01270672

University Hospital, Basel, SwitzerlandAmphetamine-Related Disorders, Mood Disorder, Substance-Related Disorders

Start: 2011-01-31End: 2011-05-31Updated: 2018-12-11

Related Papers

Acute effects of MDMA, MDA, lysine-MDMA, and lysine-MDA in a randomized, double-blind, placebo-controlled, crossover trial in healthy participants.

2025-09-25

Acute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants.

2024-08-237 citations

MDMA enhances positive affective responses to social feedback

Journal of Psychopharmacology2024-01-277 citations

Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants.

2023-05-3122 citations

Pharmacological effects of methylone and MDMA in humans

Frontiers in Pharmacology2023-02-1719 citations

Oxytocin receptor gene variations and socio-emotional effects of MDMA: A pooled analysis of controlled studies in healthy subjects

PLoS ONE2018-06-1834 citations

Human Pharmacology of Mephedrone in Comparison with MDMA.

2016-05-2077 citations

Pharmacokinetic and pharmacodynamic effects of methylphenidate and MDMA administered alone or in combination

The International Journal of Neuropsychopharmacology2013-10-08123 citations

Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study.

2012-05-04128 citations