18F fluciclovine

DRUG5 trials

Sponsors

Nghi Nguyen, Blue Earth Diagnostics, Baptist Health South Florida

Conditions

Brain CancerBrain MetastasesBrain Metastases, AdultCervical CancerUterine Cancer

Phase 1

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

RecruitingNCT04689048

Baptist Health South FloridaBrain Cancer, Brain Metastases, Brain Metastases, Adult

Start: 2022-04-04End: 2027-12-01Target: 20Updated: 2026-04-22

18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery

RecruitingNCT06048094

Baptist Health South FloridaBrain Cancer, Brain Metastases, Brain Metastases, Adult

Start: 2024-04-11End: 2033-05-01Target: 46Updated: 2026-05-20

Phase 2

Study to Establish Image Interpretation Criteria for 18F Fluciclovine PET in Detecting Recurrent Brain Metastases (PURSUE)

CompletedNCT04410367

Blue Earth DiagnosticsBrain Metastases

Start: 2020-08-31End: 2021-12-31Updated: 2025-07-20

Phase 3

Study to Establish the Diagnostic Performance of 18F Fluciclovine PET in Detecting Recurrent Brain Metastases

CompletedNCT04410133

Blue Earth DiagnosticsBrain Metastases

Start: 2020-10-26End: 2023-06-05Updated: 2025-08-28

Phase 4

Pilot Study to Assess the Potential Clinical Utility of 18F Fluciclovine PET for Cervical and Endometrial Cancer.

TerminatedNCT03423082

Nghi NguyenCervical Cancer, Uterine Cancer

Start: 2018-12-11End: 2019-12-18Updated: 2020-10-28

Related Papers

JS09.5.A18F-FLUCICLOVINE PET FOR DETECTION OF RECURRENT BRAIN METASTASES AFTER RADIATION THERAPY: IMAGE INTERPRETATION CRITERIA RESULTS FROM PURSUE, A PROSPECTIVE PHASE 2 TRIAL

Neuro-Oncology2023-09-01

NEIM-02 CHARACTERIZATION OF LARGE BRAIN METASTASES WITH18F-FLUCICLOVINE PET/CT TREATED WITH STAGED STEREOTACTIC RADIOSURGERY (SSRS): INTERIM ANALYSIS OF A PILOT STUDY

Neuro-Oncology Advances2023-08-01

NEIM-05 PURSUE: RESULTS FROM A PROSPECTIVE, PHASE 2B TRIAL TO DEFINE IMAGE INTERPRETATION CRITERIA FOR18F-FLUCICLOVINE-PET FOR DETECTION OF RECURRENT BRAIN METASTASES AFTER RADIATION THERAPY

Neuro-Oncology Advances2023-08-01

Evaluating the diagnostic performance of <sup>18</sup>F-fluciclovine for detection of recurrent brain metastases after radiation therapy: Results from a prospective phase 2 trial.

Journal of Clinical Oncology2023-06-015 citations

P15.10.B A multicenter phase 3 trial in progress: diagnostic performance of18F-fluciclovine PET for the detection of recurrent brain metastases after radiation therapy (REVELATE)

Neuro-Oncology2022-09-01

NEIM-03 A MULTICENTER PHASE 3 TRIAL IN PROGRESS: DIAGNOSTIC PERFORMANCE OF18F-FLUCICLOVINE PET FOR THE DETECTION OF RECURRENT BRAIN METASTASES AFTER RADIATION THERAPY (REVELATE)

Neuro-Oncology Advances2022-08-01

CLRM-02. TRIAL IN PROGRESS: A PROSPECTIVE, MULTICENTER PHASE 2B STUDY TO ESTABLISH IMAGE INTERPRETATION CRITERIA FOR 18F-FLUCICLOVINE PET IN DETECTING RECURRENT BRAIN METASTASES AFTER RADIATION THERAPY (PURSUE)

Neuro-Oncology Advances2021-09-21

NEIM-02. TRIAL IN PROGRESS: A MULTICENTER PHASE 3 STUDY TO ESTABLISH THE DIAGNOSTIC PERFORMANCE OF 18F-FLUCICLOVINE PET IN DETECTING RECURRENT BRAIN METASTASES AFTER RADIATION THERAPY (REVELATE)

Neuro-Oncology Advances2021-09-21

TRLS-01. Trial in Progress: A Prospective, Multicenter Phase 2b Study to Establish Image Interpretation Criteria for 18F-Fluciclovine PET in Detecting Recurrent Brain Metastases after Radiation Therapy (PURSUE)

Neuro-Oncology Advances2021-08-011 citations

TRLS-02. Trial in Progress: A Multicenter Phase 3 Study to Establish the Diagnostic Performance of 18F-Fluciclovine PET in Detecting Recurrent Brain Metastases after Radiation Therapy (REVELATE)

Neuro-Oncology Advances2021-08-01